Fungicon Capsule Mechanism of Action

Synthetic broad-spectrum bistriazole antifungal agent.
Pharmacology: Fluconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14α-demethylation. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. The subsequent loss of normal sterols correlates with the accumulation of 14α-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole.
Microbiology: Fluconazole is active against Blastomyces dermatitidis, Candida sp, Coccidioides immitis, Cryptococcus neoformans, Epidermophyton sp, Histoplasma capsulatum, Microsporum and Trichophyton spp. Resistance has developed in some Candida sp. Ketoconazole-resistant strains of C. albicans have been found to be cross-resistant to fluconazole.
Pharmacokinetics: Fluconazole is almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are 4-8 mcg/mL after repetitive doses of 100 mg. Renal excretion accounts for >90% of elimination and the elimination half-life is 25 hrs. Fluconazole diffuses readily into body fluids, including sputum and saliva; concentrations in CSF are 50-90% of the simultaneous values in plasma.